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The sudden outbreak of the COVID-19 pandemic has brought drastic changes to people’s daily lives, work, and the surrounding environment. Investigations into these changes are very important for decision makers to implement policies on economic loss assessments and stimulation packages, city reopening, resilience of the environment, and arrangement of medical resources. In order to analyze the impact of COVID-19 on people’s lives, activities, and the natural environment, this paper investigates the spatial and temporal characteristics of Nighttime Light (NTL) radiance and Air Quality Index (AQI) before and during the pandemic in mainland China. The monthly mean NTL radiance, and daily and monthly mean AQI are calculated over mainland China and compared before and during the pandemic. Our results show that the monthly average NTL brightness is much lower during the quarantine period than before. This study categorizes NTL into three classes: residential area, transportation, and public facilities and commercial centers, with NTL radiance ranges of 5–20, 20–40 and greater than 40 (nW· cm − 2 · sr − 1 ), respectively. We found that the Number of Pixels (NOP) with NTL detection increased in the residential area and decreased in the commercial centers for most of the provinces after the shutdown, while transportation and public facilities generally stayed the same. More specifically, we examined these factors in Wuhan, where the first confirmed cases were reported, and where the earliest quarantine measures were taken. Observations and analysis of pixels associated with commercial centers were observed to have lower NTL radiance values, indicating a dimming behavior, while residential area pixels recorded increased levels of brightness after the beginning of the lockdown. The study also discovered a significant decreasing trend in the daily average AQI for mainland China from January to March 2020, with cleaner air in most provinces during February and March, compared to January 2020. In conclusion, the outbreak and spread of COVID-19 has had a crucial impact on people’s daily lives and activity ranges through the increased implementation of lockdown and quarantine policies. On the other hand, the air quality of mainland China has improved with the reduction in non-essential industries and motor vehicle usage. This evidence demonstrates that the Chinese government has executed very stringent quarantine policies to deal with the pandemic. The decisive response to control the spread of COVID-19 provides a reference for other parts of the world. 

Land surface temperature (LST) is an important input to the Atmosphere–Land Exchange Inverse (ALEXI) model to derive the Evaporative Stress Index (ESI) for drought monitoring. Currently, LST inputs to the ALEXI model come from the Geostationary Operational Environmental Satellite (GOES) and Moderate Resolution Imaging Spectroradiometer (MODIS) products, but clouds affect them. While passive microwave (e.g., AMSR-E and AMSR-2) sensors can penetrate non-rainy clouds and observe the Earth’s surface, but usually with a coarse spatial resolution, how to utilize multiple instruments’ advantages is an important methodology in remote sensing. In this study, we developed a new five-channel algorithm to derive LST from the microwave AMSR-E and AMSR-2 measurements and calibrate to the MODIS and GOES LST products. A machine learning method is implemented to further improve its performance. The MODIS and GOES LST products still show better performance than the AMSR-E and AMSR-2 LSTs when evaluated against the ground observations. Therefore, microwave LSTs are only used to fill the gaps due to clouds in the MODIS and GOES LST products. A gap filling method is further applied to fill the remaining gaps in the merged LSTs and downscale to the same spatial resolution as the MODIS and GOES products. With the daily integrated LST at the same spatial resolution as the MODIS and GOES products and available under nearly all sky conditions, the drought index, like the ESI, can be updated on daily basis. The initial implementation results demonstrate that the daily drought map can catch the fast changes of drought conditions and capture the signals of flash drought, and make flash drought monitoring become possible. It is expected that a drought map that is available on daily basis will benefit future drought monitoring. 

Abstract Recognition of short linear motifs (SLiMs) or peptides by proteins is an important component of many cellular processes. However, due to limited and degenerate binding motifs, prediction of cellular targets is challenging. In addition, many of these interactions are transient and of relatively low affinity. Here, we focus on one of the largest families of SLiM‐binding domains in the human proteome, the PDZ domain. These domains bind the extreme C‐terminus of target proteins, and are involved in many signaling and trafficking pathways. To predict endogenous targets of PDZ domains, we developedMotifAnalyzer‐PDZ, a program that filters and compares all motif‐satisfying sequences in any publicly available proteome. This approach enables us to determine possible PDZ binding targets in humans and other organisms. Using this program, we predicted and biochemically tested novel human PDZ targets by looking for strong sequence conservation in evolution. We also identified three C‐terminal sequences in choanoflagellates that bind a choanoflagellate PDZ domain, theMonsiga brevicollisSHANK1 PDZ domain (mbSHANK1), with endogenously‐relevant affinities, despite a lack of conservation with the targets of a homologous human PDZ domain, SHANK1. All three are predicted to be signaling proteins, with strong sequence homology to cytosolic and receptor tyrosine kinases. Finally, we analyzed and compared the positional amino acid enrichments in PDZ motif‐satisfying sequences from over a dozen organisms. Overall,MotifAnalyzer‐PDZis a versatile program to investigate potential PDZ interactions. This proof‐of‐concept work is poised to enable similar types of analyses for other SLiM‐binding domains (e.g.,MotifAnalyzer‐Kinase).MotifAnalyzer‐PDZis available athttp://motifAnalyzerPDZ.cs.wwu.edu.